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Home » Consensus Conference on Larynx Preservation for Laryngeal/Hypopharyngeal Squamous Cell Carcinoma

Consensus Conference on Larynx Preservation for Laryngeal/Hypopharyngeal Squamous Cell Carcinoma

    Milano, 12/04/2024

    Ore 9  Registrations of participants

    09:30 Opening of the congress

    09:50- 10:20 Introduction: Presentation of the project 

    10:20 – 10:50 Session 1

    1. Granular indications for T2-T3 cancer, Indications for T4a laryngeal cancers
    2. Approved and rejected statements

    10:50- 11:20  Session 2

    1. Indications for salvage organ preservation strategies after RT failure
    2. Approved and rejected statements

    11:20- 11:50  Session 3

    1. Prognostic value of response after induction chemotherapy; Prognostic/predictive factors
    2. Approved and rejected statements

     11:50 -12:30  Session 4

    1. Cost-effectiveness of different laryngeal preservation approaches
    2. Follow-up
    3. Approved and rejected statements

    12: 30- 13:30 Light lunch


    The Preserve project: example of a tailored approach to laryngeal and hypopharyngeal cancers
    Presentation of the preliminary results of the project funded by the Era PerMed JTC2020 grant.

    14:30 – 15:30 Session 5

    1. Laryngeal function at baseline: assessment (minimal criteria for definition) and value for preservation strategies
    2. Which comorbidities are contraindications and at what extent? (neurological, cardiovascular, pulmonary)
    3. Prehabilitation and rehabilitation protocols.
    4. Approved and rejected statements

    15:30- 16:00 Session 6

    1. Organ preservation in older patients: selection criteria
    2. Approved and rejected statements

    16:00 – 16:30 Coffee break

    16:30- 17:00 Session 7

    1. Listen to patient’s preferences: tools and implementation
    2. Approved and rejected statements

    17:00 – 18:00 Session 8

    1. What changes now? What are the topics still to be clarified? Which are the not approved statements and why?
    2. New study proposal

    18:30 End of works Thanks and greetings


    Larynx Preservation represents an important option for patients affected by Locally Advanced (LA) Laryngo-Hypopharyngeal Squamous Cell Carcinoma (LHSCC), given the chance to provide a curative treatment without affecting the ability to speak. However, to date the indications for the available strategies of Larynx Preservation – i.e., surgical preservation, induction chemotherapy, and concomitant chemoradiation treatment – are still debated. International Guidelines do not provide meticulous indications, instead recommending a case-by-case discussion also keeping into consideration the expertise of each Multidisciplinary Tumour Board.

    The purpose of this Consensus Project is to dissect the topics with scanty literature, summarise the current evidence, point out the most debated questions, enlighten the fields needing further research and provide expert opinions, including those of the patients, on topics with inadequate clinical evidence.

    Methods and Topics 

    The Scientific Committee and the Scientific Young Secretariat of this Project has elected a Core Group and an Expert Group:

    • The Core Group is composed of a small number internationally recognised experts (15), representing ENT Surgeons, Radiation Oncologists, Medical Oncologists, Radiologists, Pathologists, Speech and Language Pathologists, and Dieticians, selected in Europe and North America;
    • The Expert Group is composed of a larger number of internationally recognised experts (about 50) coming from all over the world and representing all the specialisations previously listed. Also, Patients’ Representatives are included in the Expert Group.

    For each topic the following rules have been applied:

    • Define absolute contraindications and contraindications specific to each treatment approach;
    • Discuss radiological indications;
    • Discuss available clinical/biochemical predictor of organ preservation success;
    • Define the expected functional outcome;
    • Discuss differences between hypopharynx and larynx.

    Level of evidence and literature references have been reported for each statement.

    The final statements list havehas been voted according to a two-round Delphi consensus method by the members of the Core Group and the Expert Group. Votes have been expressed according to the Likert scale (1-5), and comments have been collected. Statements have been approved if a consensus of ≥ 80% is reached within the first round, otherwhile they have been reviewed by the members of the Core Group taking into consideration also eventful comments, and then a second round with the same cut-off for approval took place.

    The Scientific Committee

    Prof Piero Nicolai (Padua, Italy)

    Prof Roberto Maroldi (Brescia, Italy)

    Prof Paolo Bossi (Humanitas Milan, Italy)

    Dr Marco Ferrari (Padua, Italy)

    The Scientific Young Secretariat

    Dr Francesca Mularoni (Padua, Italy)

    Dr Piergiorgio Gaudioso (Padua, Italy)

    Dr Davide Smussi (Brescia, Italy)

    Organisations supporting the project:

    • University of Padova and Azienda Ospedaliera Universitaria Padova
    • ASST Spedali Civili Brescia and University of Brescia
    • Humanitas Cancer Center and Humanitas University, Rozzano, Milano
    • Fondazione Regionale per la Ricerca Biomedica (Regione Lombardia)

    Endorsement requested to:

    • EHNS
    • ESMO
    • ESTRO
    • AIOCC
    • GONO
    • Cancer Patients Europe